Accepted for Publication: March 9, 2011.
Published Online: May 9, 2011. doi:10.1001/archneurol.2011.108
Author Contributions:Study concept and design: Machulda, Jones, McDade, and Jack. Acquisition of data: Knopman, Petersen, and Jack. Analysis and interpretation of data: Machulda, Jones, Vemuri, Avula, Przybelski, Boeve, and Jack. Drafting of the manuscript: Machulda. Critical revision of the manuscript for important intellectual content: Jones, Vemuri, McDade, Avula, Przybelski, Boeve, Knopman, Petersen, and Jack. Statistical analysis: Machulda, Jones, Vemuri, and Przybelski. Obtained funding: Petersen and Jack. Administrative, technical, and material support: Jones, Boeve, Petersen, and Jack. Study supervision: Jack.
Financial Disclosure: Dr Boeve has served as an investigator for clinical trials sponsored by Cephalon, Inc, and Allon Pharmaceuticals; receives royalties from the publication of a book titled Behavioral Neurology Of Dementia (Cambridge Medicine; 2009); and has received honoraria from the American Academy of Neurology. Dr Knopman serves as an associate editor of Neurology; served on a data safety monitoring board for sanofi-aventis; and is an investigator in a clinical trial sponsored by Elan Pharmaceutical and Forest Laboratories. Dr Petersen has served as a consultant to GE Healthcare and has served on a data safety monitoring board for Elan and Wyeth Pharmaceuticals. Dr Jack serves as a consultant for Elan, Eisai, Janssen, and GE Inc.
Funding/Support: This study was supported by National Institute of Health grants R01-AG11378 (Dr Vemuri), P50-AG16574 and U01-AG06786 (Dr Petersen), and AG11378; National Institute on Aging grants P50 AG16574, U01 AG06786, and RO1 AG32306 (Dr Boeve) and R01-AG11378, P50-AG16574, and U01 AG024904-01 (Dr Jack); a Robert H. Smith Family Foundation Research Fellowship (Dr Vemuri); Center for Inherited Disease Research grant U24 AG026395 (Dr Boeve); an Alexander Family Alzheimer's Disease Research Professorship of the Mayo Foundation (Dr Jack); the Mayo Clinic Department of Psychiatry and Psychology Small Grants Program; and the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program of the Mayo Foundation.
Additional Contributions: Brian Gregg, BS, Guang Zeng, PhD, and Ankit Master, MS, provided technical support.