Accepted for Publication: February 15, 2011.
Author Contributions:Study concept and design: Kumar and Boeve. Acquisition of data: Boeve, Duffy, Woodruff, Nair, Ellison, Kuntz, Jack, Westmoreland, Baker, Rademakers, and Parisi. Analysis and interpretation of data: Boeve, Boot, Orr, Ellison, Kantarci, Fields, Baker, Rademakers, Parisi, and Dickson. Drafting of the manuscript: Kumar, Boeve, and Boot. Critical revision of the manuscript for important intellectual content: Boot, Orr, Duffy, Woodruff, Nair, Ellison, Kuntz, Kantarci, Jack, Westmoreland, Fields, Baker, Rademakers, Parisi, and Dickson. Administrative, technical, and material support: Boeve, Boot, Kuntz, Kantarci, Jack, Baker, Rademakers, and Parisi. Study supervision: Kumar and Boeve.
Financial Disclosure: Dr Boeve has served as an investigator for clinical trials sponsored by Cephalon, Inc and Allon Pharmaceuticals; receives royalties from the publication of a book entitled Behavioral Neurology of Dementia (Cambridge Medicine, 2009); has received honoraria from the American Academy of Neurology; and receives research support from the National Institute on Aging (P50 AG16574 [as a coinvestigator], U01 AG06786 [coinvestigator], and RO1 AG32306 [coinvestigator]) and the Center for Inherited Disease Research (U24 AG026395 [coinvestigator]).
Funding/Support: These research activities were supported by grants P50 AG16574 and PO1 AG07216 from the National Institute on Aging and R01 NS065782 from the National Institute of Neurological Disorders and Stroke.
Additional Contributions: We are particularly thankful to the patients and their relatives for participating in this research.