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Serum Insulinlike Growth Factor 1 as Possible Marker for Risk and Early Diagnosis of Parkinson Disease

Jana Godau, MD; Katharina Knauel; Karin Weber; Kathrin Brockmann, MD; Walter Maetzler, MD; Gerhard Binder, MD; Daniela Berg, MD
Arch Neurol. 2011;68(7):925-931. doi:10.1001/archneurol.2011.129.
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Background The level of serum insulinlike growth factor 1 (IGF-1) is increased in idiopathic Parkinson disease (PD).

Objectives To assess whether the (1) IGF-1 level is increased in patients with PD at the time of diagnosis, (2) increased IGF-1 level is related to impaired motor function in healthy individuals, and (3) detection of increased IGF-1 level will help to identify persons at risk for PD.

Design Cross-sectional cohort study.

Main Outcome Measures Serum IGF-1 was measured in 15 patients with newly diagnosed untreated PD and 139 healthy elderly individuals. Participants at risk for PD (n = 11) were defined as having altered motor function according to the Unified Parkinson's Disease Rating Scale, Part III (UPDRS-III), and dopaminergic dysfunction as indicated by sonographically determined substantia nigra hyperechogenicity.

Results The IGF-1 level was higher in patients with PD compared with healthy participants (P = .004) and inversely correlated with the UPDRS-III score (ρ = −0.77). The IGF-1 level was not related to motor function in the healthy group. However, there was no significant difference between the IGF-1 level in the at-risk subgroup vs the PD patients (corrected P = .15), and the IGF-1 level was positively correlated with the UPDRS-III score (ρ = 0.80).

Conclusion Serum IGF-1 monitoring may be valuable in the diagnosis of PD and for the identification of individuals with a putatively increased risk for PD.

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Figure 1. Study design and subgroups. iPD indicates idiopathic Parkinson disease (PD); M−/SN−, normal motor function and substantia nigra (SN) echogenicity; M−/SN+, normal motor function but SN hyperechogenicity; M+/SN−, impaired motor function but normal SN echogenicity; M+/SN+, impaired motor function and SN hyperechogenicity; TCS, transcranial B-mode sonography; UPDRS-III, Unified Parkinson's Disease Rating Scale, Part III.




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