Accepted for Publication: January 5, 2011.
Published Online: March 14, 2011. doi:10.1001/archneurol.2011.36
Author Contributions:Study concept and design: Landt, Holland, Aigbirhio, Menon, Baron, and Zaman. Acquisition of data: Landt, D'Abrera, Aigbirhio, Fryer, and Canales. Analysis and interpretation of data: Holland, Fryer, Hong, Menon, Baron, and Zaman. Drafting of the manuscript: Landt, D'Abrera, and Zaman. Critical revision of the manuscript for important intellectual content: D'Abrera, Holland, Aigbirhio, Fryer, Canales, Hong, Menon, Baron, and Zaman. Obtained funding: Holland, Aigbirhio, and Zaman. Administrative, technical, and material support: Landt, D'Abrera, Aigbirhio, Fryer, Canales, Menon, and Zaman. Study supervision: Holland and Zaman.
Financial Disclosure: None reported.
Funding/Support: This work was supported by the Medical Research Council; Cambridge National Institute for Health Research Biomedical Research Centre; Wellcome Trust; Royal College of Anaesthetists; the Down's Syndrome Association; and the Health Foundation.
Additional Contributions: We are grateful to people with DS and their families and support workers for their commitment and to the staff at the Wolfson Brain Imaging Centre for their help. We thank the Down's Syndrome Association, Medical Research Council, Cambridge National Institute for Health Research Biomedical Research Centre, the National Institute for Health Research Collaborations in Leadership for Applied Health Research and Care for Cambridgeshire and Peterborough, the Wellcome Trust, the Royal College of Anaesthetists, and the Health Foundation. We thank William E. Klunk, MD, PhD, and Chester A. Mathis, PhD, for kindly providing dosimetry and toxicology data for [11C]PiB.