0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Correspondence |

How Safe Could Intrathecal Transplantation of Mesenchymal Stem Cells Be Considered in Multiple Sclerosis?—Reply

Dimitrios Karussis, MD, PhD; Adi Vaknin-Debminsky, MD, PhD; Oded Abramsky, MD, PhD; Ibrahim Kassis, PhD; Panayiota Petrou, MD; Tamir Ben Hur, MD, PhD
Arch Neurol. 2011;68(7):955-956. doi:10.1001/archneurol.2011.162.
Text Size: A A A
Published online

Extract

In reply

Karacostas and colleagues express their concerns about safety issues arising from our trial with MSCs in MS and ALS.1 Our detailed responses to each question raised follow.

Concerning general safety issues, in our phase I/II study, our main goal was to investigate the feasibility and short-term safety of the treatment modality. We were able to rule out any short-term toxicity, as shown by the 6-month follow-up. Additionally, as mentioned in the manuscript, we followed up the patients for up to 3 years and were not confronted with any exceptional clinical change. We performed yearly MRI scans in all patients that did not reveal any unexpected pathology (up to at least 3 years) and continued to show stabilization and suppression of the disease (follow-up data not yet published). We definitely share the concerns regarding unknown long-term toxicities, especially because previous experience with other treatments of MS (natalizumab, linomide) has shown that small-scale trials are not sensitive enough to rule out all possible adverse effects. This is clearly underlined in our conclusions that “ . . . larger studies are warranted to establish the long term safety and efficacy of this modality. . . . ”

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

July 1, 2011
Dimitris Karacostas, MD, PhD; George Hadjigeorgiou, MD, PhD; Panos Ioannidis, MD, PhD; Ioannis Milonas, MD, PhD
Arch Neurol. 2011;68(7):955-956. doi:10.1001/archneurol.2011.161.
CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

36 Views
0 Citations
×

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();