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How Safe Could Intrathecal Transplantation of Mesenchymal Stem Cells Be Considered in Multiple Sclerosis?

Dimitris Karacostas, MD, PhD; George Hadjigeorgiou, MD, PhD; Panos Ioannidis, MD, PhD; Ioannis Milonas, MD, PhD
Arch Neurol. 2011;68(7):955-956. doi:10.1001/archneurol.2011.161.
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We read with considerable interest the exploratory study by Karussis et al1 on the safety of intrathecally transplanted mesenchymal stem cells (MSCs) in patients with multiple sclerosis (MS) and those with amyotrophic lateral sclerosis (ALS). Nevertheless, the data presented in that study1 do not clearly support the positive conclusion drawn, at least in MS.

More specifically, the scientific basis of the intrathecal route is limited because there is only 1 relevant study on the animal disease model.2 Additionally, there is, to our knowledge, no scientific evidence that the presence of MSCs within the central nervous system (CNS) is an absolute necessity for the effect these cells might have in autoimmune demyelination.

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July 1, 2011
Dimitrios Karussis, MD, PhD; Adi Vaknin-Debminsky, MD, PhD; Oded Abramsky, MD, PhD; Ibrahim Kassis, PhD; Panayiota Petrou, MD; Tamir Ben Hur, MD, PhD
Arch Neurol. 2011;68(7):955-956. doi:10.1001/archneurol.2011.162.
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