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Correspondence |

Laryngospasm and “Sudden Unexpected Death Related to Medullary Brain Lesions”

J. Howard Jaster, MD
Arch Neurol. 2011;68(3):395-399. doi:10.1001/archneurol.2011.18.
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I read with interest the article by Pittock et al1 describing 9 cases of paraneoplastic jaw dystonia and laryngospasm associated with antineuronal nuclear autoantibody type 2 (anti-ri).

Of the 9 patients described,1 2 patients with breast carcinoma died of paraneoplastic brain manifestations. Patient 3 experienced “sudden death at home” following a period of recurrent laryngospasms, and “autopsy findings were consistent with asphyxiation secondary to laryngospasm.” Neuropathological examination showed significant medullary brain involvement as a component of an overall picture of chronic encephalomyelitis. Patient 4 “died unexpectedly” after persistent jaw dystonia contributing to weight loss due to poor nutrition. Autopsy was refused; however, clinical findings taken together were consistent with medullary brain involvement.

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March 1, 2011
John H. Growdon, MD; A. Zara Herskovits, MD, PhD
Arch Neurol. 2011;68(3):395-399. doi:10.1001/archneurol.2011.22.
March 1, 2011
Alejandro A. Rabinstein, MD
Arch Neurol. 2011;68(3):395-399. doi:10.1001/archneurol.2011.16.
March 1, 2011
Joshua N. Goldstein, MD, PhD; Marisela Marrero, MD; Shihab Masrur, MD; Muhammad Pervez, MD; Alex M. Barrocas, MD; Abdul Abdullah, MD; Alexandra Oleinik, BS; Jonathan Rosand, MD, MS; Eric E. Smith, MD, MPH; Walter H. Dzik, MD; Lee H. Schwamm, MD
Arch Neurol. 2011;68(3):395-399. doi:10.1001/archneurol.2011.10.
March 1, 2011
Sanjay Pandey, MD, DM
Arch Neurol. 2011;68(3):395-399. doi:10.1001/archneurol.2011.9.
March 1, 2011
David Kuhlmann, MD
Arch Neurol. 2011;68(3):395-399. doi:10.1001/archneurol.2011.15.
March 1, 2011
Sanjay Pandey, MD, DM
Arch Neurol. 2011;68(3):395-399. doi:10.1001/archneurol.2011.15a.
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