0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Correspondence |

Possible Influence of Stroke Etiology on Hemorrhagic Transformation Following Thrombolysis in Warfarin-Treated Patients

Dar Dowlatshahi, MD, PhD; Martin O’Donnell, MB, PhD; Mukul Sharma, MD, MSc
Arch Neurol. 2010;67(11):1413. doi:10.1001/archneurol.2010.286.
Text Size: A A A
Published online

Extract

We read with great interest the article by Prabhakaran et al.1 We noted a significant imbalance in cardioembolic stroke between the groups (76.9% for the warfarin sodium group vs 38.3% for the controls) that was not included in the multivariable model because the overall effect of TOAST classification2 on the exploratory analysis failed to meet their prespecified inclusion criteria. Further, the small sample size of warfarin-treated patients (n = 13) precludes assessment of the association between international normalized ratio and outcome within a robust multivariable model. It is likely that the reported rate of post–tissue plasminogen activator (EPA) intracerebral hemorrhage associated with premorbid warfarin use was confounded by a higher propensity for hemorrhagic transformation in cardioembolic stroke.3,4

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

69 Views
0 Citations
×

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
Jobs
JAMAevidence.com

Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, 3rd ed
Assessing the Strength of Recommendations: The GRADE Approach

Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, 3rd ed
Are the Results Valid?

brightcove.createExperiences();