Accepted for Publication: October 9, 2012.
Published Online: March 18, 2013. doi:10.1001/jamaneurol.2013.1342
Author Contributions: Dr Rodrigue had full access to all the data in the study and takes responsibility for the integrity of the data. Study concept and design: Rodrigue, Kennedy, Devous, and Park. Acquisition of data: Rodrigue, Rieck, Kennedy, Devous, and Diaz-Arrastia. Analysis and interpretation of data: Rodrigue, Devous, Diaz-Arrastia, and Park. Drafting of the manuscript: Rodrigue, Rieck, and Devous. Critical revision of the manuscript for important intellectual content: Rodrigue, Kennedy, Devous, Diaz-Arrastia, and Park. Statistical analysis: Rodrigue and Devous. Obtained funding: Rodrigue, Kennedy, Diaz-Arrastia, and Park. Administrative, technical, and material support: Rieck and Diaz-Arrastia. Study supervision: Kennedy, Diaz-Arrastia, and Park.
Conflict of Interest Disclosures: The radiotracer was provided at no cost to the study by Avid Radiopharmaceuticals Inc. Dr Devous serves on the advisory board of Avid Radiopharmaceuticals. Avid Radiopharmaceuticals is supporting a longitudinal component of this study.
Funding/Support: This study was supported by National Institutes of Health grants 5R37AG-006265-25, 3R37AG-006265-25S1, and P30AG12300 and Alzheimer's Association grant IIRG-09-135087 (Dr Park). Dr Rodrigue was supported in part by National Institute on Aging grant 1K99-AG-036848-2.
Additional Contributions: We thank Michael Viguet, BS, ARRT(N), for assistance with positron emission tomography scanning, Chris Paliotta, BA, for collecting blood samples, and Prasanna Tamil, MS, and Erin Wooden, BS, for participant testing and scheduling.