Accepted for Publication: April 18, 2012.
Published Online: January 28, 2013. doi:10.1001/jamaneurol.2013.607
Author Contributions: Dr Roberts had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Roberts, Geda, Pankratz, Ivnik, and Petersen. Acquisition of data: Roberts, Geda, Knopman, Boeve, Tangalos, Ivnik, and Petersen. Analysis and interpretation of data: Roberts, Knopman, Cha, Pankratz, Mielke, and Petersen. Drafting of the manuscript: Roberts, Cha, and Petersen. Critical revision of the manuscript for important intellectual content: Roberts, Geda, Knopman, Pankratz, Boeve, Tangalos, Ivnik, Mielke, and Petersen. Statistical analysis: Cha and Pankratz. Obtained funding: Roberts, Tangalos, and Petersen. Administrative, technical, and material support: Roberts, Boeve, Ivnik, and Petersen. Study supervision: Roberts, Ivnik, and Petersen.
Conflict of Interest Disclosures: Dr Knopman serves as deputy editor for Neurology, serves on a data safety monitoring board for Lilly Pharmaceuticals, is an investigator in a clinical trial sponsored by Elan Pharmaceuticals, and receives research support from the National Institutes of Health (grants R01 AG011378, P50 AG016574, U01 AG006786, AG029550, AG032306, and U01 096917). Dr Petersen reported that he serves on scientific advisory boards for Pfizer Inc, Janssen Alzheimer Immunotherapy, Elan Pharmaceuticals, and GE Healthcare; has given a CME lecture for Novartis Inc; receives royalties from the publication of a book entitled Mild Cognitive Impairment (Oxford University Press, 2003); and receives research support from the National Institute on Aging (grants P50 AG016574 [principal investigator] and U01 AG006786 [principal investigator]) and the National Institutes of Health (grants R01 AG011378 [coinvestigator] and U01 AG024904 [coinvestigator]). Dr Roberts currently receives research support from the National Institute on Aging (grant U01 AG006786 [coinvestigator]), Abbott Laboratories, and the Driskill Foundation and previously received support through grant K01 AG028573 (principal investigator). Dr Tangalos served on a data safety monitoring board for Lilly Pharmaceuticals, remains an advisor to Lilly Pharmaceuticals, and is an investigator with Baxter.
Funding/Support: This research was supported by the National Institutes of Health (grants P50 AG016574, U01 AG006786, K01 MH068351, and K01 AG028573) and the Robert H. and Clarice Smith and Abigail van Buren Alzheimer's Disease Research Program and was made possible by the Rochester Epidemiology Project (grant R01 AG034676 from the National Institute on Aging).
Role of the Sponsors: The sponsors of this study did not participate in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.