Sep 2012, Vol 69, No. 9 >

< Previous Article

Full Content is available to subscribers

Subscribe/Learn More

Next Article >

Original Contribution | Sep 2012

Association of Cerebral Microbleeds in Acute Ischemic Stroke With High Serum Levels of Vascular Endothelial Growth Factor

Pooja Dassan, MD, MRCP; Martin M. Brown, MD, FRCP; Simone M. Gregoire, MD; Geoffrey Keir, PhD, FRCPath; David J. Werring, PhD, MRCP

Arch Neurol. 2012;69(9):1186-1189. doi:10.1001/archneurol.2012.459.

Text Size: A A A

Published online

Article

Figures

Tables

References

Comments

ABSTRACT

Objective To determine whether vascular endothelial growth factor (VEGF) levels are associated with the presence of cerebral microbleeds (CMBs) in patients after acute ischemic stroke.

Design A cross-sectional study that used blood samples obtained within 24 hours of symptom onset from patients who experienced acute stroke to measure VEGF levels by enzyme immunoassay. A validated CMB rating scale was used to analyze acutely acquired magnetic resonance images, with the rater blind to clinical details and VEGF levels.

Setting Accident and Emergency Department at University College Hospital, London, England.

Patients Twenty patients who experienced acute ischemic stroke.

Main Outcome Measures Presence of CMBs and serum level of VEGF.

Results Five of the 20 patients with acute ischemic stroke (25%) had CMBs. The median VEGF level in the CMB group was significantly higher than that in the group without CMBs (P = .003).

Conclusion An increase in vascular permeability secondary to a raised VEGF level may have a role in the genesis of CMBs in patients with acute ischemic stroke.

Figures in this Article

Sign In to Access Full Content

Username

Password

Forgot Your Password?

Don't have Access?

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

Figures

Place holder to copy figure label and caption

Grahic Jump Location

View Large | Save Figure | Download Slide (.ppt) | View in Article Context

Figure 1. Schematic illustrations of axial brain magnetic resonance images showing the index infarct (solid gray color) and the location of the cerebral microbleeds (CMBs) (black dots with a faint gray halo) for the 5 patients (numbered 1-5) with CMBs.

Place holder to copy figure label and caption

Grahic Jump Location

View Large | Save Figure | Download Slide (.ppt) | View in Article Context

Figure 2. Box and whisker plots of serum vascular endothelial growth factor (VEGF) levels in patients who experienced ischemic stroke with cerebral microbleeds (CMBs) compared with those without CMBs. The horizontal line inside each box indicates the median; the top and bottom of each box denote the 75th and 25th percentiles, respectively; and the ends of the whiskers represent the minimum and maximum values (the outlier is indicated by an open circle). A statistically significant difference existed between these 2 subgroups (P = .003). This difference remained significant even after excluding the outlier high VEGF value from the group with CMBs (P = .01).

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

Correspondence

Submit a Letter

CME

Accreditation Information

The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit^TM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 Credit^TM.

Note: You must get at least of the answers correct to pass this quiz.

Clear Answers | Save For Later

You have not filled in all the answers to complete this quiz

The following questions were not answered:

Sorry, you have unsuccessfully completed this CME quiz with a score of

The following questions were not answered correctly:

Commitment to Change (optional):

Indicate what change(s) you will implement in your practice, if any, based on this CME course.

Your quiz results:

The filled radio buttons indicate your responses. The preferred responses are highlighted

For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes

Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).

Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.

All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.

Instructions

Thank you for submitting a comment on this article. It will be reviewed by JAMA Neurology editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.

Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.

* = Required Field

Comment Author(s)* (if multiple authors, separate names by comma)

Example: John Doe

Affiliation & Institution*

Disclosure of Any Conflicts of Interest* Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.

Please disclose any conflicts of interest or check the box below.

No potential conflicts or relevant financial interests

Comment Title*

Comment*

Get Audio Code

Submit Cancel

Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Print
PDF
Email

AMA

You must be logged in and have an account to share content.

Return to: Association of Cerebral Microbleeds in Acute Ischemic Stroke With High Serum Levels of Vascular Endothelial Growth Factor

This feature is provided as a courtesy. By using it you agree that that you are requesting the material solely for personal, non-commercial use, and that it is subject to the AMA's Terms of Use. The information provided in order to email this article will not be shared, sold, traded, exchanged, or rented. Please refer to The JAMA Network's Privacy Policy for additional information.

© 2013 American Medical Association. All Rights Reserved.
Share
Get Citation

Dassan P, Brown MM, Gregoire SM, Keir G, Werring DJ. Association of Cerebral Microbleeds in Acute Ischemic Stroke With High Serum Levels of Vascular Endothelial Growth Factor. Arch Neurol. 2012;69(9):1186-1189. doi:10.1001/archneurol.2012.459.

Download citation file:

RIS (Zotero)

EndNote

BibTex

Medlars

ProCite

RefWorks

Reference Manager

© American Medical Association
Get Permissions
Get Alerts

Processing your request... Please Wait.
Submit a Letter
Submit a Comment

Sign In to Access Full Content

Username

Password

Forgot Your Password?

Full Content is available to subscribers

Association of Cerebral Microbleeds in Acute Ischemic Stroke With High Serum Levels of Vascular Endothelial Growth Factor

ABSTRACT

Figures in this Article

Topics

Sign In to Access Full Content

Don't have Access?

Figures

Tables

Interactive Graphics

Video

References

Correspondence

Sign In

Don't have Access?

Sign In to Access Full Content

Related Content

JAMA Neurology

Content

Services

The JAMA Network

Sites

AMA Publishing Group Journals

Information For

Services

Content Resources

Other Resources

Sign In

Register for a FREE personal account

Want to Subscribe?

Don't have Access?

Forgot Your Password?